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Updated: Jun 7, 2026
06:51
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Linking cell polarity, aging and rejuvenation
Arie Budovsky1, Vadim E Fraifeld, Stella Aronov
1The Shraga Segal Department of Microbiology and Immunology, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Biogerontology
|October 28, 2010
Summary
Cell polarity mechanisms in yeast influence aging and rejuvenation by segregating damaged components. Further research may reveal similar processes in human stem cells, linking polarity to longevity.
Area of Science:
- Cell Biology
- Gerontology
- Molecular Biology
Background:
- Cell polarity is fundamental to biological processes.
- Its role in aging and age-related diseases requires further investigation.
- Budding yeast studies reveal links between polar processes and cellular aging/rejuvenation.
Purpose of the Study:
- To explore the role of cell polarity in aging and rejuvenation.
- To investigate if yeast polarity mechanisms apply to germ and stem cell division.
- To identify common genes associated with cell polarity and longevity.
Main Methods:
- Analysis of polar segregation of damaged proteins and extrachromosomal DNA (ERCs) in yeast.
- Investigation of asymmetric inheritance of multidrug resistance (MDR) proteins.
- Comparative genomics to identify shared genes between polarity and longevity pathways.
Main Results:
- Polar processes in yeast, including protein segregation and transport, are linked to mother cell aging and daughter cell rejuvenation.
- A septin-based diffusion barrier facilitates the removal of damaged components.
- Numerous genes are shared between cell polarity and longevity pathways.
Conclusions:
- Cell polarity plays a significant role in aging and rejuvenation processes.
- The budding yeast Saccharomyces cerevisiae is a valuable model for studying these links.
- Future research should explore mammalian equivalents of yeast polarity mechanisms for biogerontological insights.
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