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Updated: Jun 7, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
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Standardization of thromboelastography: values and challenges.

Meera Chitlur1, Jeanne Lusher

  • 1Carman and Ann Adams Department of Pediatrics, Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA. mchitlur@med.wayne.edu

Seminars in Thrombosis and Hemostasis
|October 28, 2010
PubMed
Summary

Standardizing thromboelastography (TEG/ROTEM) is crucial for its clinical use. This working group

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Area of Science:

  • Coagulation science
  • Hemostasis research
  • Clinical laboratory diagnostics

Background:

  • Plasma-based hemostasis assays have been standard for decades.
  • The cell-based model revived interest in global coagulation assays like thromboelastography (TEG/ROTEM).
  • Current TEG/ROTEM methods lack standardization, limiting clinical comparability and reliability.

Purpose of the Study:

  • To summarize efforts by the TEG-ROTEM Working Group to standardize thromboelastography.
  • To highlight challenges encountered during the standardization process.
  • To emphasize the need for continued standardization for clinical relevance.

Main Methods:

  • Review of standardization efforts by the TEG-ROTEM Working Group.
  • Analysis of challenges in achieving assay comparability.
  • Discussion of the current state of thromboelastography methodology.

Main Results:

  • Significant differences in current thromboelastography methods hinder result comparability.
  • Standardization is critical for translating TEG/ROTEM from research to clinical practice.
  • This represents the first major effort to standardize TEG/ROTEM.

Conclusions:

  • Continued work on thromboelastography standardization is essential.
  • Standardization will enable investigation into the clinical utility of TEG/ROTEM.
  • The goal is to establish TEG/ROTEM as a reliable tool for evaluating hemostasis in real-time.