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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

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Related Experiment Video

Updated: Jun 7, 2026

Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

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Published on: October 30, 2010

[Two autopsy cases with systemic amyloidosis--case 11/2010].

S Schott1, F Artunc, M Haap

  • 1Institut für Pathologie, Universitätsklinikum Tübingen, Tübingen.

Deutsche Medizinische Wochenschrift (1946)
|October 28, 2010
PubMed
Summary

This study examines two cases of amyloidosis, a rare disease. Acquired forms like AL and AA amyloidosis have a poor prognosis, especially with cardiac or vascular complications.

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Last Updated: Jun 7, 2026

Performing and Processing FNA of Anterior Fat Pad for Amyloid
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Area of Science:

  • Nephrology
  • Hematology
  • Pathology

Background:

  • Amyloidosis encompasses a spectrum of diseases characterized by extracellular deposition of misfolded proteins.
  • Acquired forms, including AL and AA amyloidosis, represent the majority of cases.

Observation:

  • Two patients presented with distinct clinical scenarios: one with gastrointestinal symptoms and the other with liver failure.
  • Investigations revealed AL amyloidosis in Case 1 and AA amyloidosis secondary to familial Mediterranean fever in Case 2.
  • Both patients experienced severe complications, including refractory nephrotic syndrome, circulatory failure, and hepatic flare, ultimately leading to fatal outcomes.

Findings:

  • Case 1: AL amyloidosis with increased bone marrow plasma cells (20-30%).
  • Case 2: AA amyloidosis secondary to familial Mediterranean fever, with co-existing Hepatitis B and C.
  • Autopsy was performed on both cases.

Implications:

  • The prognosis for amyloidosis, particularly acquired AL and AA types, remains poor.
  • Cardiac and vascular involvement significantly worsens the outlook for patients with amyloidosis.