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Updated: Jun 7, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
[One-stage management of infected nonunion using granulated cancellous bone autografting after debridement]
Wei-Ju Lu1, Bin Li, Hong-Bo Qian
1Department of Orthopedics, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China. tianyazhichi2@sina.com
Objective:
To investigate the curative effect of treating infected nonunion with debridement and granulated cancellous bone autografting in a one-stage procedure.
Methods:
Between 1999 and 2005, 38 cases of infected nonunion were treated with immediate granulated cancellous bone autografting after debridement.
Results:
At a mean follow-up of 44 months (range: 12 to 93), 33/38 (86.8%) had an excellent outcome, 5 (13.2%) developed infectious recurrent and/or persistent nonunion (1 case with infectious recurrence and persistent nonunion). Two patients suffered refracture after removing external fixator.
Conclusion:
The success rate of treating infected nonunion with debridement and granulated cancellous bone autografting in one-stage is high.