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Updated: Jun 7, 2026
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
[Microsurgical treatment of giant cell tumor of skull]
Yong Cui1, Xu-Yi Zong, Shu-Yu Hao
1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 10050, China.
Objective:
To explore the diagnosis and microsurgical treatment of giant cell tumor (GCT) of skull.
Methods:
The investigators reviewed the clinical features, operative approach and prognosis of 23 consecutive cases of GCT of skull operated at our department between July 2000 and November 2008.
Results:
Headache was the most common presenting symptom (86.96%) found among the patients with GCT of skull. Besides, the symptoms induced by the consequent lesions of II-XII intracranial nerves were also commonly observed. The mean duration of symptoms was 29.3 months and the mean preoperative KPS (Karnofsky performance scale) was 76 +/- 6. Among these cases, 10 tumors occurred in sphenoid bone, 9 in temporal bone, 3 in posterior fossa and 1 in frontal bone. Gross total resections were achieved in 6 cases, subtotal resections in 10 cases and partial resections in 7 cases. There was no operative death case. The follow-up data of 18 patients (78.26%) were collected with a mean follow-up duration of 35.5 months. All patients lived in normal postoperative life.
Conclusion:
GCT of skull is a generally low-degree malignancy showing a local bone invasion mostly in sphenoid and temporal bones.
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