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[The clinico-pathological manifestation of cardiac involvement in eosinophilic diseases]

Zhuang Tian1, Quan Fang, Da-chun Zhao

  • 1Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Zhonghua Nei Ke Za Zhi
|October 29, 2010
PubMed

Insights

Eosinophilic diseases can severely affect the heart, causing conditions like myocardial infarction and heart failure. Early diagnosis and treatment of cardiac involvement in eosinophilic disorders are crucial for improving patient outcomes.

Area of Science:

  • Cardiology
  • Hematology
  • Pathology

Context:

  • Eosinophilic diseases encompass a group of disorders characterized by excessive eosinophil accumulation.
  • Cardiac involvement is a significant but often under-recognized complication of these diseases.
  • Understanding the clinical and pathological spectrum is vital for timely diagnosis and management.

Purpose:

  • To investigate the clinical manifestations and pathological findings of eosinophilic diseases with cardiac involvement.
  • To correlate biopsy/autopsy findings with clinical presentation and diagnostic criteria.
  • To highlight the impact of cardiac complications on patient prognosis.

Summary:

  • Seven patients with eosinophilic diseases (idiopathic hypereosinophilic syndrome or Churg-Strauss syndrome) and cardiac involvement were analyzed.
  • Clinical presentations included angina, heart failure, and sudden death, with characteristic ECG and echocardiographic findings.
  • Pathological examination revealed eosinophilic infiltration, vasculitis, myocardial necrosis, and fibrosis, sometimes affecting coronary arteries.

Impact:

  • Cardiovascular complications are a leading cause of morbidity and mortality in eosinophilic diseases.
  • Early recognition of cardiac involvement is essential for initiating appropriate treatment.
  • Treatment with steroids and immunosuppressants can potentially improve prognosis in affected individuals.
Abstract

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