Related Experiment Video

Updated: Jun 7, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

[Correlation between high sensitive C-reactive protein, lipoprotein(a), blood uric acid and severity of coronary

Ping He1, Xian-he Xie, Yi-peng Ding

  • 1Emergency Center, Hainan Provincial People's Hospital, Haikou 570102, China.

Zhonghua Yi Xue Za Zhi
|October 29, 2010
PubMed

Insights

High sensitive C-reactive protein (hs-CRP), lipoprotein (Lp)(a), and blood uric acid (BUA) are linked to coronary artery disease (CAD) severity. Measuring these markers together can help evaluate high-risk individuals and guide clinical interventions for CAD.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Atherosclerosis Research

Context:

  • Coronary artery disease (CAD) poses a significant global health burden.
  • Identifying reliable biomarkers for CAD risk stratification and severity assessment is crucial.
  • Inflammatory and metabolic factors are increasingly recognized in CAD pathogenesis.

Purpose:

  • To investigate the association between high sensitive C-reactive protein (hs-CRP), lipoprotein (Lp)(a), and blood uric acid (BUA) with the severity of coronary artery disease (CAD).

Summary:

  • This study analyzed 813 patients undergoing coronary arteriography, categorizing them into normal and CAD groups based on stenosis.
  • Elevated levels of hs-CRP, Lp(a), and BUA were significantly associated with the presence and severity of CAD, including multi-vessel disease.
  • Logistic regression identified hs-CRP, Lp(a), and BUA as independent risk factors for CAD.

Impact:

  • Findings suggest that hs-CRP, Lp(a), and BUA play a role in the development and progression of CAD.
  • Combined detection of these biomarkers offers value in assessing high-risk populations and patient conditions.
  • This research provides a basis for proactive clinical management and intervention strategies for coronary heart disease.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...