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Updated: Jun 7, 2026
On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis
Published on: May 31, 2020
[The correlation between combining 1p/19q LOH and pathology in gliomas]
Xiao-hui Ren1, Xiang-li Cui, Song Lin
1Beijing Neurosurgical Institute, Beijing 100050, China.
Objective:
To investigate the frequencies of combining loss of heterozygosity (LOH) of chromosome 1p/19q in gliomas of different pathologies and analyze the clinical factors correlated with combining LOH by logistic regression.
Methods:
Tumor samples from 127 glioma patients were collected. The status of 1p and 19q was evaluated by fluorescence in situ hybridization (FISH) and the frequencies of combining 1p/19q LOH in gliomas of different pathologies were analyzed.
Results:
The frequencies of combining 1p/19q LOH in astrocytic, oligoastrocytic and oligodendroglial tumors were 19.30%, 50.00% and 80.77% respectively. The frequencies of combining 1p/19q LOH in oligoastrocytic and oligodendroglial tumors were higher than those in astrocytic tumors (P < 0.01) and the frequencies of combining 1p/19q LOH in oligodendroglial tumors was higher than those in oligoastrocytic tumors (P < 0.05). The frequencies of 1p/19q LOH in astrocytic, oligoastrocytic and oligodendroglial tumors were 12.28%, 11.36 and 0 respectively. There was no significant correlation between combining 1p/19q LOH and age, gender and grade by logistic regression.
Conclusion:
In gliomas, combining 1p/19q LOH is proved to be the most common pattern of chromosome deletion involving 1p or 19q. It is significantly correlated with oligodendroglial component. Combining 1p/19q LOH may be valuable in the diagnosis, treatment and prognostic prediction for glioma with oligodendroglial component.
