Related Experiment Video
Updated: Jun 7, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Synthesis of chalcone (3-(4-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one): advantage of sonochemical method over
K J Jarag1, D V Pinjari, A B Pandit
1Dyestuff Technology Department, Institute of Chemical Technology, Matunga, Mumbai, India.
Abstract:
In this work, an attempt was made to synthesize chalcone (3-(4-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one) by condensation of 4-fluorobenzaldehyde with 1-(4-methoxyphenyl)ethanone under basic conditions by using both conventional (NUS) and sonochemical (US) methods. A simple condensation reaction of 4-fluorobenzaldehyde and 1-(4-methoxyphenyl)ethanone using potassium hydroxide as a base was carried out for the study. The synthesized chalcone derivative was characterized for FTIR, NMR, elemental analyses and studied for XRD, PSM, TGA and SEM properties to evaluate its performance obtained under ultrasonic energy. It was observed that complete conversion to chalcone occurred in 10 min by sonochemical method and in 4h by conventional method. Also it was found that crystallinity of the US synthesized chalcone was found to be increased by 63% than that of NUS synthesized chalcone. Finally, it has been observed that chalcone synthesis using sonochemical method is an energy efficient technique over conventional method (almost 90% of energy saving).
Related Concept Videos
Prochirality
Sharpless Epoxidation
Preparation and Reactions of Sulfides
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Ketones with Nonenolizable Aromatic Aldehydes: Claisen–Schmidt Condensation
As the self-condensation of ketones is generally not favored in basic conditions, the self-condensed products do not form in the reaction between ketones and benzaldehyde. The general reaction of Claisen–Schmidt condensation is...
Multiple Halogenation of Methyl Ketones: Haloform Reaction
