Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural basis for EtfD-mediated coupling of β-oxidation and the respiratory chain in mycobacteria.

The EMBO journal·2026
Same author

Natural Selection in Transcription Factor-DNA Interaction Motifs: A Comparative and Population Genomics Perspective.

Genome biology and evolution·2025
Same author

Mycobacterial EtfD contains an unusual linear [3Fe-4S] cluster and enables β-oxidation to drive proton pumping by the electron transport chain.

bioRxiv : the preprint server for biology·2025
Same author

Bedaquiline Activity against Leprosy.

The New England journal of medicine·2025
Same author

Combination therapy enhances the antiviral activity of IFN-λ against SARS-CoV-2 and MERS-CoV.

Virus research·2025
Same author

Real-time evaluation of macozinone activity against <i>Mycobacterium tuberculosis</i> through bacterial nanomotion analysis.

Antimicrobial agents and chemotherapy·2024
Same journal

Host-derived proteomic biomarkers for discriminating the tuberculosis disease spectrum in a Brazilian cohort.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Association between gut microbiota and white matter microstructural damage in tuberculous meningitis patients.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Context-dependent transcriptional and epigenetic reprogramming shapes neutrophil antimicrobial and immunoregulatory functions in tuberculosis.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Discovery and identification of a handwritten laboratory notebook by Albert Calmette and Camille Guérin describing experimental studies and development of the BCG vaccine for tuberculosis at the Institut Pasteur.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Delineating the potential of bioenergetics in drug discovery against Mycobacteriumabscessus.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Association of vitamin D status with the immune response in active pulmonary tuberculosis patients with chronic pulmonary aspergillosis.

Tuberculosis (Edinburgh, Scotland)·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

TubercuList--10 years after.

Jocelyne M Lew1, Adamandia Kapopoulou, Louis M Jones

  • 1Ecole Polytechnique Fédérale de Lausanne, Global Health Institute, Station 19, CH-1015 Lausanne, Switzerland. jocelyne.lew@epfl.ch

Tuberculosis (Edinburgh, Scotland)
|October 29, 2010
PubMed
Summary
This summary is machine-generated.

TubercuList, a database for Mycobacterium tuberculosis H37Rv, has released its 20th version. It now includes updated gene information, new gene discoveries, and links to crucial research data for tuberculosis studies.

Related Experiment Videos

Last Updated: Jun 7, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Area of Science:

  • Microbiology
  • Bioinformatics
  • Genomics

Background:

  • TubercuList is a relational database for Mycobacterium tuberculosis H37Rv.
  • It has been active for ten years and is now on its twentieth release.

Purpose of the Study:

  • To describe recent updates to the TubercuList database.
  • To highlight manual curation efforts and new gene discoveries.
  • To emphasize its role in facilitating tuberculosis research.

Main Methods:

  • Manual annotation of genome-derived information from scientific literature.
  • Integration of bioinformatics and experimental data for gene coordinate updates.
  • Inclusion of gene essentiality data and functional information.

Main Results:

  • Discovery of new, small genes and updated coordinates for existing coding sequences.
  • Annotation of polymorphic nucleotides and updated gene essentiality data.
  • Inclusion of protein and RNA activities, and links to specialized databases and PubMed.

Conclusions:

  • TubercuList provides current, manually curated gene-based information for Mycobacterium tuberculosis.
  • It serves as a valuable, comprehensive resource for tuberculosis research, linking diverse datasets.
  • The database supports basic and translational research with extensive, updated information.