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Related Experiment Video

Updated: Jun 7, 2026

An Automated Method to Perform The In Vitro Micronucleus Assay using Multispectral Imaging Flow Cytometry
12:56

An Automated Method to Perform The In Vitro Micronucleus Assay using Multispectral Imaging Flow Cytometry

Published on: May 13, 2019

Reflections on the development of micronucleus assays.

John A Heddle1, Michael Fenech, Makoto Hayashi

  • 1Department of Biology, York University, Toronto, Ontario M3J 1P3, Canada.

Mutagenesis
|October 29, 2010
PubMed
Summary

This article reflects on the development of micronucleus assays for measuring genetic damage. These methods are now standard tools in toxicology and genetic research across many species.

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Last Updated: Jun 7, 2026

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Published on: May 13, 2019

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Area of Science:

  • * Genetics and Toxicology
  • * Biomarker Development

Background:

  • * Historical overview of micronucleus assay development by key researchers.
  • * Focus on personal experiences rather than a comprehensive historical account.

Observation:

  • * Over 6000 papers published utilizing micronucleus assays.
  • * Widespread application in diverse tissues and organisms, from plants to humans.
  • * Primary focus on mammalian erythrocytes and human lymphocytes.

Findings:

  • * Evolution of micronucleus testing as a standard method for assessing genetic damage.
  • * Personal insights into the challenges and successes in method development and acceptance.

Implications:

  • * Understanding the historical context of widely adopted genotoxicity testing methods.
  • * Valuable resource for researchers in genetics, toxicology, and related fields.
  • * Highlights the journey of scientific method validation and integration into standard practice.