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Untreated type 2 diabetes and its complications are associated with subcortical infarctions
Rosebud O Roberts1, Kejal Kantarci, Yonas E Geda
1Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. roberts.rosebud@mayo.edu
Objective:
To investigate the association of type 2 diabetes with subcortical infarctions.
Research Design And Methods:
We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging.
Results:
The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11-6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects.
Conclusions:
These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.
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