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Related Experiment Videos

Menstrual irregularity and cardiovascular mortality.

Erica T Wang¹, Piera M Cirillo, Eric Vittinghoff

¹Center for Research on Women's and Children's Health, Public Health Institute, University of California San Francisco, San Francisco, California 94115, USA.

The Journal of Clinical Endocrinology and Metabolism

|October 29, 2010

Summary

This summary is machine-generated.

Women with irregular menstrual cycles showed a higher risk of coronary heart disease (CHD) mortality. This increased risk was reduced after accounting for body mass index, suggesting its role in cardiovascular risk.

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Area of Science:

Reproductive Endocrinology
Cardiovascular Epidemiology
Women's Health

Background:

Polycystic ovary syndrome (PCOS) is a common cause of irregular menstrual cycles and is linked to poor cardiovascular health.
Prospective studies on the association between PCOS and cardiovascular mortality are limited.

Purpose of the Study:

To investigate the prospective association between irregular menstrual cycles and cardiovascular mortality.
To examine the specific risks for coronary heart disease (CHD) and cerebrovascular disease mortality.

Main Methods:

A cohort of 15,005 pregnant women (1959-1966) was studied, with menstrual cycle patterns assessed at baseline.
Participants were tracked until 2007 for cardiovascular disease (CVD), CHD, and cerebrovascular disease deaths using vital status files.
Cox proportional hazards models were used to estimate mortality risks, with missing data handled by multiple imputation.

Main Results:

Over 456,000 person-years, 666 CVD deaths occurred, including 301 CHD and 149 cerebrovascular deaths.
Women with irregular cycles had a higher age-adjusted risk for CHD mortality (HR 1.42), but this was not statistically significant after BMI adjustment (HR 1.35).
A nonsignificant increase in overall CVD mortality risk was observed (HR 1.21), with no increased risk for cerebrovascular mortality (HR 0.85).

Conclusions:

Irregular menstrual cycles were associated with an increased age-adjusted risk of coronary heart disease mortality in this cohort.
The observed association between irregular cycles and CHD mortality risk was attenuated after adjustment for body mass index.