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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

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ICOStomizing immunotherapies with T(H)17.

Johan Garaude1, J Magarian Blander

  • 1Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

Science Translational Medicine
|October 29, 2010
PubMed
Summary

New research shows that Inducible Costimulatory Molecule (ICOS) signaling supports the growth of human T helper 17 (T(H)17) cells, which may fight tumors. These findings offer new avenues for cancer immunotherapy development.

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