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Factors influencing the one- and two-year growth response in children treated with growth hormone: analysis from an

Judith Ross1, Peter A Lee, Robert Gut

  • 1Department of Pediatrics, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA.

International Journal of Pediatric Endocrinology
|October 29, 2010
PubMed

Insights

Growth hormone (GH) treatment shows positive height standard deviation score (ΔHSDS) changes in pediatric patients. Younger, prepubertal children experienced greater growth, highlighting the importance of early intervention for conditions like GHD.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Clinical Research

Background:

  • Understanding factors influencing growth in pediatric endocrine disorders is crucial for effective treatment.
  • Growth hormone deficiency (GHD) and other conditions affect linear growth in children.
  • Previous studies suggest age and pubertal status may impact growth response to GH therapy.

Purpose of the Study:

  • To evaluate gender, pubertal, and age-related differences in height standard deviation score changes (ΔHSDS) in pediatric patients.
  • To analyze growth responses in children with various growth-related conditions receiving GH therapy.
  • To determine optimal timing for initiating GH treatment based on patient characteristics.

Main Methods:

  • Analysis of data from 5,797 GH-naïve pediatric patients (<18 years) from the ANSWER Program registry.
  • Inclusion criteria: GHD, multiple pituitary hormone deficiency (MPHD), Turner syndrome (TS), small for gestational age (SGA), Noonan syndrome (NS), and idiopathic short stature (ISS).
  • Assessment of ΔHSDS at year 1, stratified by gender, pubertal status, and age groups.

Main Results:

  • Overall positive ΔHSDS observed across all patient groups.
  • SGA males showed significantly greater ΔHSDS than females at year 1 (P = .016).
  • Prepubertal patients with GHD exhibited greater ΔHSDS than pubertal patients.
  • Younger children (boys <11 years, girls <10 years) demonstrated greater ΔHSDS across GHD, MPHD, and ISS cohorts (P < .05).

Conclusions:

  • Early initiation of GH treatment is crucial for maximizing growth response in pediatric patients.
  • Younger, prepubertal children generally show enhanced growth responses to GH therapy.
  • Age and pubertal status are significant factors influencing treatment outcomes in various pediatric growth disorders.

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