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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: Jun 7, 2026

A Rat Model of Compound Acne
03:10

A Rat Model of Compound Acne

Published on: November 1, 2024

Acne scars: pathogenesis, classification and treatment.

Gabriella Fabbrocini1, M C Annunziata, V D'Arco

  • 1Division of Clinical Dermatology, Department of Systematic Pathology, University of Naples Federico II, Via Sergio Pansini 5, 80133 Napoli, Italy.

Dermatology Research and Practice
|October 29, 2010
PubMed
Summary
This summary is machine-generated.

Acne scars, resulting from inflammatory acne, impact quality of life. This review covers acne scar causes, types, and diverse treatment options for better patient outcomes.

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A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
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A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

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Last Updated: Jun 7, 2026

A Rat Model of Compound Acne
03:10

A Rat Model of Compound Acne

Published on: November 1, 2024

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
05:54

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

Area of Science:

  • Dermatology
  • Medical Science

Background:

  • Acne affects over 90% of adolescents, persisting into adulthood for 12-14% of cases.
  • Inflammatory acne lesions can lead to acne scars, causing significant psychological and social distress.
  • Acne scars are broadly classified into atrophic and hypertrophic types.

Purpose of the Study:

  • To summarize the current understanding of acne scar pathogenesis.
  • To outline the classification of different acne scar types.
  • To review the various treatment modalities available for acne scars.

Main Methods:

  • Literature review of pathogenesis, classification, and treatment of acne scars.
  • Synthesis of information on chemical peels, dermabrasion, laser therapy, punch techniques, and other interventions.
  • Compilation of data on treatments for both atrophic and hypertrophic scars.

Main Results:

  • Acne scar pathogenesis is not fully elucidated, with multiple hypotheses proposed.
  • A wide array of treatments exist for atrophic scars, including peels, lasers, and needling.
  • Hypertrophic and keloidal scars are managed with therapies like silicone gels, cryotherapy, and surgery.

Conclusions:

  • Understanding acne scar pathogenesis is crucial for developing effective treatments.
  • A diverse range of treatment options are available, often used in combination.
  • Effective management of acne scars can improve patients' psychological well-being and social interactions.