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Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Renal Drug Clearance: Overview01:06

Renal Drug Clearance: Overview

Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Acute Kidney Injury III: Clinical Manifestations

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Related Experiment Video

Updated: Jun 7, 2026

Intravascular Delivery of Biologics to the Rat Kidney
07:29

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

Scleroderma renal crisis: a pathology perspective.

Ibrahim Batal1, Robyn T Domsic, Thomas A Medsger

  • 1Department of Pathology, University of Pittsburgh Medical Center, A614 Scaife Hall, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

International Journal of Rheumatology
|October 29, 2010
PubMed
Summary
This summary is machine-generated.

Scleroderma renal crisis (SRC), a severe systemic sclerosis complication, involves kidney damage and hypertension. Renal biopsies are crucial for diagnosis and management, though kidney transplant outcomes for these patients remain suboptimal.

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Last Updated: Jun 7, 2026

Intravascular Delivery of Biologics to the Rat Kidney
07:29

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

Area of Science:

  • Nephrology
  • Rheumatology
  • Pathology

Background:

  • Scleroderma renal crisis (SRC) is a rare but serious complication of systemic sclerosis (SSc).
  • SRC is characterized by increased vascular permeability, coagulation activation, and renin secretion, leading to acute renal failure and hypertension.
  • Histologically, SRC presents as thrombotic microangiopathy affecting small renal vessels.

Purpose of the Study:

  • To highlight the diagnostic and prognostic significance of renal biopsies in SSc patients with SRC.
  • To discuss the role of renal biopsies in differentiating SRC from other causes of renal failure in SSc.
  • To review current management strategies and outcomes, including kidney transplantation, for SRC.

Main Methods:

  • Review of the clinical, histological, and management aspects of Scleroderma Renal Crisis.
  • Analysis of the role of renal biopsy in diagnosis, prognosis, and patient management.
  • Evaluation of kidney transplantation outcomes in SSc patients.

Main Results:

  • Renal biopsies are essential for confirming SRC diagnosis, excluding other renal pathologies, and guiding patient management.
  • Histologic findings include myxoid intimal changes, thrombi, onion skin lesions, and fibrointimal sclerosis.
  • Kidney transplantation may be necessary for end-stage renal failure, but outcomes for SSc patients are currently suboptimal.

Conclusions:

  • Renal biopsy is critical for the accurate diagnosis and management of Scleroderma Renal Crisis in systemic sclerosis.
  • Despite advances, kidney transplantation outcomes for SSc patients with SRC remain a challenge requiring further investigation and improvement.