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Development of a multicommutated flow system with chemiluminometric detection for quantification of gentamicin in

Lúcia H M L M Santos1, A N Araújo, Boaventura Reis

  • 1REQUIMTE, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4050-047 Porto, Portugal.

Journal of Automated Methods & Management in Chemistry
|October 29, 2010
PubMed

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Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...