Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Functional outcomes, arthrofibrosis and residual laxity following arthroscopic and open reduction and internal fixation of tibial spine fractures: A systematic review and meta-analysis.

The Knee·2026

Same author

Radiomics for bone tumour diagnosis and management.

Clinical radiology·2025

Same author

Impact of renal-adjusted ceftazidime/avibactam in patients with KPC-producing <i>Klebsiella pneumoniae</i> bloodstream infection: a retrospective cohort study.

JAC-antimicrobial resistance·2024

Same author

COVID-19 and kidney: role of SARS-CoV-2 infection in the induction of renal damage.

European review for medical and pharmacological sciences·2023

Same author

Kidney dysfunction is associated with adverse outcomes in internal medicine COVID-19 hospitalized patients.

European review for medical and pharmacological sciences·2023

Same author

Arthroscopic surgery or exercise therapy for degenerative meniscal lesions: a systematic review of systematic reviews.

Musculoskeletal surgery·2022

Search research articles

Related Experiment Video

Updated: Jun 7, 2026

In Vitro Impact Model to Generate Sublethal Chondrocyte Injury in Bovine Cartilage Explants

In Vitro Impact Model to Generate Sublethal Chondrocyte Injury in Bovine Cartilage Explants

Published on: June 27, 2025

Blood exposure has a negative effect on engineered cartilage.

C Sosio¹, F Boschetti, L Mangiavini

¹Department of Orthopaedics and Traumatology, San Raffaele Scientific Institute, Milan, Italy.

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA

|October 29, 2010

Summary

This summary is machine-generated.

Blood exposure during engineered cartilage development delays maturation by impacting chondrocyte activity. Further research is needed to create protective scaffolds for cartilage repair strategies.

More Related Videos

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Published on: January 7, 2019

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

Published on: November 3, 2019

Related Experiment Videos

Last Updated: Jun 7, 2026

In Vitro Impact Model to Generate Sublethal Chondrocyte Injury in Bovine Cartilage Explants

In Vitro Impact Model to Generate Sublethal Chondrocyte Injury in Bovine Cartilage Explants

Published on: June 27, 2025

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants

Published on: January 7, 2019

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

Published on: November 3, 2019

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Native cartilage damage from blood exposure is known.
The impact of blood on engineered cartilage remains unclear.
Autologous chondrocyte implantation is a key surgical technique for cartilage repair.

Purpose of the Study:

To assess the in vitro effects of varying blood concentrations on engineered cartilage.
To evaluate both immediate and long-term impacts of blood contact on cartilage properties.

Main Methods:

Swine articular chondrocytes were cultured and seeded onto collagen membranes.
Constructs were exposed to different peripheral blood concentrations for 3 days.
Samples were analyzed immediately post-exposure and after 21 days of standard culture.

Main Results:

Engineered cartilage showed increased weight and matrix production.
Blood exposure caused a dose-dependent decrease in mitochondrial activity.
Partial recovery of mitochondrial activity was observed after prolonged culture.

Conclusions:

A 3-day blood exposure delays engineered cartilage maturation and affects chondrocyte activity.
Findings highlight the need for protective scaffold materials in cartilage repair.
Further material science research is recommended to mitigate blood-induced damage.