[In vitro antibacterial activity of new oxime type of beta-lactam antibiotics]

The antibacterial efficacy of two novel beta-lactam antibiotics of the oxime type, VUFB 16265 and 16272, was evaluated by determining the minimal inhibitory concentration (MIC) in 47 clinical strains and 6 standard strains (Staphylococcus aureus, Streptococcus pyogenes and faecalis, E. coli, Enterobacter and Proteus spec., Pseudomonas aeruginosa), which were the most frequent causes of infectious complications. The results were compared with the MIC of cefalexin, cefoxitin, cefazolin, cefsulodin, and ampicillin. The antibacterial activity of both VUFB drugs was comparable with the efficacy of the antibiotics tested. Only in the strains of Pseudomonas aeruginosa the activity of all antibiotics under evaluation was low and only cefsulodin was effective.