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Updated: Aug 12, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

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Published on: March 7, 2019

[Intracerebral hemorrhage related with cerebral amyloid angiopathy]

H Q Xu1

  • 1Department of Biophysics, Shanghai Medical University.

Zhonghua Shen Jing Jing Shen Ke Za Zhi = Chinese Journal of Neurology and Psychiatry
|December 1, 1990
PubMed

Insights

Cerebral amyloid angiopathy (CAA) causes intracerebral hemorrhages, often in cerebral lobes. Pathological findings reveal thickened arteries with amyloid deposits and luminal stenosis, confirming CAA as a cause of bleeding in the brain.

Area of Science:

  • Neuropathology
  • Vascular Neurology

Context:

  • Cerebral amyloid angiopathy (CAA) is a significant cause of spontaneous intracerebral hemorrhage (ICH), particularly in the elderly.
  • Understanding the pathological hallmarks of CAA-related ICH is crucial for diagnosis and management.

Purpose:

  • To report the clinical and neuropathologic findings in 11 patients with intracerebral hemorrhages associated with cerebral amyloid angiopathy.
  • To characterize the morphological changes in cerebral vessels in cases of CAA-related ICH.

Summary:

  • Eleven cases of intracerebral hemorrhage attributed to CAA were analyzed, with patient ages ranging from 45 to 79 years (average 61.8).
  • Hematomas were predominantly located in cerebral lobes, with two cases involving the basal ganglia and thalamus. All hemorrhages ruptured into the ventricles and/or subarachnoid space.
  • Neuropathologic examination revealed thickened leptomeningeal and cortical arteries, deposition of homogeneously eosinophilic material, luminal stenosis, and characteristic amyloid birefringence on Congo red staining.

Impact:

  • This study highlights the specific neuropathologic features of CAA-related intracerebral hemorrhages.
  • Findings contribute to the understanding of the pathogenesis of CAA and its association with cerebrovascular events.
  • Provides insights into the vascular changes that predispose to lobar and deep intracerebral bleeds in the context of CAA.

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