Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subclassification of peripheral dopamine receptors.

O E Brodde1

  • 1Biochemisches Forschungslabor, Medizinische Klinik, Universitätsklinikum Essen, Germany.

Journal of Autonomic Pharmacology
|January 1, 1990
PubMed
Summary

Two dopamine (DA) receptor subtypes exist in the periphery, differentiated by antagonist potencies. Further research will clarify if these subtypes fully explain peripheral DA effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The contribution of reactive oxygen species and p38 mitogen-activated protein kinase to myofilament oxidation and progression of heart failure in rabbits.

British journal of pharmacology·2010
Same author

Regulation of equine lymphocyte beta-adrenoceptors under the influence of clenbuterol and dexamethasone.

Equine veterinary journal·2002
Same author

Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart.

Basic research in cardiology·2002
Same author

Noradrenaline-induced increase in protein synthesis in adult rat cardiomyocytes: involvement of only alpha1A-adrenoceptors.

Naunyn-Schmiedeberg's archives of pharmacology·2001
Same author

Muscarinic receptors in the mammalian heart.

Pharmacological research·2001
Same author

Impaired beta-adrenergic control of immune function in patients with chronic heart failure: reversal by beta1-blocker treatment.

Basic research in cardiology·2001

Area of Science:

  • Pharmacology
  • Neuroscience
  • Molecular Biology

Background:

  • Dopamine (DA) exerts diverse effects in the periphery.
  • Understanding peripheral DA receptor subtypes is crucial for elucidating these effects.

Purpose of the Study:

  • To present evidence for two distinct peripheral dopamine receptor subtypes.
  • To differentiate these subtypes based on antagonist potencies.

Main Methods:

  • Pharmacological characterization using specific antagonists.
  • Analysis of antagonist potency order at different receptor subtypes.

Main Results:

  • Evidence suggests two peripheral DA receptor subtypes, tentatively named DA-1 and DA-2.
  • DA-1 receptors show higher potency for SCH 23390 over domperidone.
  • DA-2 receptors exhibit greater potency for domperidone than SCH 23390.

Conclusions:

  • The identified peripheral DA receptor subtypes can be distinguished by antagonist selectivity.
  • Future molecular biology and pharmacological studies are needed to confirm if this subclassification is sufficient or if further subtypes exist.

Related Experiment Videos