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Updated: Aug 18, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
[Current aspects of the therapy of bronchial asthma in childhood]
W Leupold1, P Wunderlich, W Thal
1Abteilung Bronchopneumologie, Medizinischen Akademie, Carl Gustav Carus Dresden.
Insights
Effective asthma management focuses on symptom reduction and preventing irreversible airway obstruction. Treatment involves environmental control, self-management training, and stepwise pharmacotherapy tailored to age and severity, prioritizing inhaled medications.
Area of Science:
- Allergy and Immunology
- Pulmonology
- Pediatric Medicine
Context:
- Asthma management requires a multi-faceted approach considering patient age and disease severity.
- Current guidelines emphasize stepwise treatment strategies to control symptoms and prevent long-term lung damage.
- Environmental factors, allergen avoidance, and patient education are crucial components of comprehensive asthma care.
Purpose:
- To outline age-appropriate and severity-based management goals and strategies for asthma.
- To review the stepwise application of pharmacotherapy, including bronchodilators, anti-inflammatory agents, and corticosteroids.
- To highlight the importance of environmental control and self-management in optimizing asthma outcomes.
Summary:
- Key management goals include symptom reduction, enabling a normal lifestyle, and preventing irreversible airway obstruction across all age groups.
- Treatment modalities encompass environmental manipulation, psychotherapeutic management, severity assessment, self-management training, hyposensitization, and pharmacotherapy.
- Pharmacotherapy is age- and severity-dependent, progressing stepwise from preferred beta-2-stimulants to inhaled corticosteroids and lastly oral corticosteroids, with sodium cromoglycate and ketotifen useful in childhood.
Impact:
- Provides a framework for clinicians to tailor asthma management plans effectively.
- Emphasizes the integration of pharmacological and non-pharmacological interventions for improved patient outcomes.
- Contributes to the understanding of optimal therapeutic progression for diverse asthma patient populations.
Abstract:
The management goals common to all age groups are to reduce symptoms, to permit a normal physically active lifestyle, and to prevent irreversible airway obstruction. Main measures are environmental manipulation (avoidance of allergen contact, cigarette smoke and pets; psychotherapeutic management), assessment of severity, training for self management, hyposensitization (pollen, HDM, insect venoms) and pharmacotherapy. Medication should be adapted to age and severity of the disease, and the different drugs should be used stepwise. The first step includes the application of bronchodilators in which beta-2-stimulants are to be preferred. If we use spacers or jet nebulizers infants can also be treated successfully. The value of xanthines is discussed controversially. The next steps tend to reduce the inflammatory reaction. In this direction sodium cromoglycate and ketotifen are useful especially in childhood, and inhaled steroids have increasing importance. The use of oral corticosteroids should be the last step.
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