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Updated: Aug 11, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
[The fundamental pulmonary mechanics processes in pressure-limited artificial ventilation of neonates]
1Abteilung Neonatologie, Universitätskinderklinik, Humboldt-Universität zu Berlin.
Abstract:
During the past years the incidence of artificial ventilation in newborn and premature babies increased continuously. The optimization of the respirator therapy requires the knowledge of the fundamental lung mechanic processes during the artificial ventilation. Using the simple model RC V(t) + V(t) = CP(t) the relationships between the flow, volume and pressure signals were demonstrated. This model was also used to explain the development of the inadvertent PEEP as well as to determine lung mechanic parameters from the measured signals. In the future the monitoring of tidal volume will be an integrated part of the respirator. Therefore, the influence of the lung mechanics and the parameter-settings of the respirator on the ventilation has been investigated in detail.
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