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Some central effects of opipramol given repeatedly
1Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Polish Journal of Pharmacology and Pharmacy
|September 1, 1990
Summary
Repeated opipramol treatment in rodents enhanced responses to amphetamine and clonidine, and reduced immobility in a behavioral despair test. These findings suggest antidepressant-like effects with chronic opipramol administration.
Area of Science:
- Neuropharmacology
- Behavioral Neuroscience
Background:
- Opipramol is a tricyclic compound with anxiolytic properties.
- Its central nervous system effects, particularly with repeated administration, require further elucidation.
Purpose of the Study:
- To investigate the central nervous system effects of acute and repeated opipramol administration in rodent models.
- To compare opipramol's effects with those of known antidepressant drugs.
Main Methods:
- Rodents (rats and mice) were administered opipramol acutely or repeatedly (14 days, twice daily).
- Locomotor activity, amphetamine-induced hyperactivity and stereotypy, clonidine-induced aggression, and behavioral despair tests were conducted.
Main Results:
- Repeated opipramol administration increased (+)-amphetamine-induced hyperactivity and enhanced clonidine-induced aggression in mice.
- A single dose of opipramol prolonged immobility in rats, while repeated doses reduced it.
- Opipramol did not affect locomotor activity or amphetamine-induced stereotypy.
Conclusions:
- Repeated opipramol treatment exhibits antidepressant-like properties in behavioral models.
- These effects are likely mediated by enhanced dopaminergic and alpha 1-adrenoceptor activity in specific brain regions.