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Lack of genotoxic activity of metronidazole and P1 derivative in two eukaryotic tests
M Konopacka1, E Grzybowska, J Michalska
1Department of Tumor Biology, Institute of Oncology, Gliwice, Poland.
Polish Journal of Pharmacology and Pharmacy
|September 1, 1990
Abstract:
Metronidazole [1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole] and P1 derivative [1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole] were investigated for their genotoxic activity in two eukaryotic tests: mitotic recombination in yeast and micronucleus test in mice. Both compounds showed no genotoxicity in these eukaryotic assays contrary to their well-documented mutagenic activity in microbial short-term tests.