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Synthesis of two new angiotensin II analogs
R Paruszewski1, R Matusiak, W Janiec
1Department of Pharmaceutical Chemistry, Medical Academy, Warszawa, Poland.
Polish Journal of Pharmacology and Pharmacy
|September 1, 1990
Abstract:
The synthesis of two new angiotensin II analogs: [Des-Arg2, epsilon Ahx1]-angiotensin (II (1) and [Des-His0)-angiotensin (II (2) is reported. Rather strong agonist activity shows analog (1)-78% and weak-analog (2)-30% of the contractile activity of angiotensinamide. None of the synthesized peptides has antagonist activity.