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Related Experiment Videos

Particles resembling C-type oncornaviruses in normal rat prostate.

N K Zeller, N Bashierelahi, R J Sydiskis

    Cancer Research
    |September 1, 1978
    PubMed
    Summary

    Researchers discovered oncornavirus-like particles in normal rat prostate tissue. These immature C-type particles were observed budding from epithelial cells, a novel finding in this tissue.

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    Area of Science:

    • Veterinary Pathology
    • Oncology
    • Cell Biology

    Background:

    • Oncornaviruses are retroviruses known to cause various diseases in animals.
    • Previous research has not documented the presence of such viral particles in normal rat prostates.

    Purpose of the Study:

    • To investigate and report the presence of virus-like particles in normal rat prostatic tissue.
    • To characterize the morphology of these observed particles.

    Main Methods:

    • Transmission electron microscopy was utilized to examine ultrathin sections of normal rat ventral prostate tissue.
    • Morphological analysis focused on identifying and characterizing viral particle structures within epithelial cells.

    Main Results:

    • Numerous particles resembling immature C-type oncornaviruses were identified in the ventral lobe of normal rat prostates.
    • These particles, approximately 100 nm in diameter with an electron-lucent core, were observed budding into intercellular spaces of lumenal epithelial cells.
    • Neither intracellular A-type nor mature C-type particles were detected.

    Conclusions:

    • This study presents the first report of oncornavirus-like particles in normal rat prostatic tissue.
    • The findings suggest a potential, previously unrecognized viral association with normal rat prostate epithelium.
    • Further research is warranted to determine the nature and significance of these particles.

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