[Comparative evaluation of the gastric transit of floating and non-floating matrix dosage forms]

The gastric transit of floating and non-floating matrix dosage forms has been studied by means of a gamma scintigraphic imaging technique. Results indicate that, on the one hand, buoyancy and non-buoyancy of the forms lead to distinct intragastric behaviours and that, on the other hand, a selective gastric retention is operated in function of the diametral size of the matrix. Depending on the subject posture, standing or supine, the gastric residence period of the form is hence determined either by its buoyancy or by its size. As sustained drug delivery systems, the floating dosage forms globally offer several advantages which might be worth taking into account.