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Related Experiment Videos

Methodology for analyzing clinical neurological data: ACTH in multiple sclerosis.

W G Henderson, W W Tourtellotte, A R Potvin

    Clinical Pharmacology and Therapeutics
    |August 1, 1978
    PubMed
    Summary

    Adrenocorticotropic hormone (ACTH) treatment improved multiple sclerosis (MS) exacerbations compared to placebo. This study re-evaluated neurological data, confirming ACTH

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    DeepSite: protein-binding site predictor using 3D-convolutional neural networks.

    Bioinformatics (Oxford, England)·2017

    Area of Science:

    • Neurology
    • Clinical Trials
    • Immunology

    Background:

    • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
    • Acute exacerbations of MS require effective treatment strategies.
    • Adrenocorticotropic hormone (ACTH) has been investigated for MS treatment.

    Purpose of the Study:

    • To re-evaluate quantitative neurological data from a clinical trial comparing ACTH and placebo for MS exacerbations.
    • To assess the efficacy of ACTH in improving neurological function in MS patients.
    • To develop a simplified method for interpreting treatment outcomes.

    Main Methods:

    • A multicenter clinical trial conducted between 1965-1968 compared ACTH with placebo.
    • Quantitative neurological examination data were re-evaluated.

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  • Data were transformed to express patient scores as a percentage of age- and sex-matched normal function.
  • Composite neurological functions over time were analyzed.

    • Main Results:

    • The re-evaluated data support previous findings of ACTH's positive effects.
    • ACTH treatment demonstrated efficacy in improving neurological function during MS exacerbations.
    • The new methodology simplifies the interpretation of patient recovery.

    Conclusions:

    • ACTH is an effective treatment for acute exacerbations of multiple sclerosis.
    • The novel data analysis method enhances the understanding of treatment-induced neurological recovery.
    • This approach aids clinicians in assessing patient progress towards normal function.