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Role of HLA class II molecules expressed on hematopoietic progenitor cells
F Mascle1, N Mooney, A Devergie
1Laboratoire d'Immunogénétique Moléculaire, Institut des Cordeliers, Paris, France.
Nouvelle Revue Francaise D'Hematologie
|January 1, 1990
Abstract:
The fixation of monoclonal antibodies (MoAb) to the molecule HLA-DR induced an augmentation of thymidine uptake by bone marrow cells, an increased formation of granulo-monocytic colonies and the activation of membrane phospholipase C (PLC) in hematopoietic progenitor cell (HPC) population. The molecule DR expressed on HPC is therefore implicated in signal transduction leading to hematopoietic differentiation.