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Changes in the lipid peroxide status of broiler chickens in acute monensin poisoning
Abstract:
The effect exerted by overdosage of monensin, an ionophore antibiotic, on the lipid peroxide status of broiler chickens was studied. Three-week-old broiler cockerels were given 150 mg monensin/kg body mass through a tube, and the malondialdehyde (MDA) concentration, glutathione peroxidase (GSH-Px) and catalase activity of the liver and breast muscle, and MDA concentration and GSH-Px activity of the blood plasma were determined. Liver MDA and catalase values rose rapidly and significantly during the experimental period. GSH-Px activity initially decreased, then tended to rise. Blood plasma and breast muscle variables did not change during the experiment. Acute monensin poisoning induced substantial enhancement of lipid peroxidation processes in the liver, while it did not appreciably affect the lipid peroxide status of the blood plasma and breast muscle. The role of the observed phenomenon in the rather complex pathogenesis of monensin poisoning is not known sufficiently. Further studies are needed to elucidate the problem.
Insights
Overdosing broiler chickens with monensin, an ionophore antibiotic, significantly increased lipid peroxidation in the liver but not in blood plasma or breast muscle. Further research is needed to understand monensin poisoning
Area of Science:
- Animal Science
- Toxicology
- Biochemistry
Background:
- Monensin is an ionophore antibiotic commonly used in poultry.
- Overdosage can lead to toxicity, but its specific effects on oxidative stress markers are not fully understood.
- Lipid peroxidation is a marker of oxidative damage.
Purpose of the Study:
- To investigate the impact of monensin overdosage on lipid peroxide status in broiler chickens.
- To determine the effects on malondialdehyde (MDA), glutathione peroxidase (GSH-Px), and catalase in liver, breast muscle, and blood plasma.
Main Methods:
- Three-week-old broiler cockerels were administered 150 mg monensin/kg body mass.
- Measurements included MDA concentration, GSH-Px activity, and catalase activity in liver, breast muscle, and blood plasma.
- Data were analyzed for significant changes during the experimental period.
Main Results:
- Liver MDA and catalase levels significantly increased post-monensin administration.
- GSH-Px activity in the liver showed an initial decrease followed by a tendency to rise.
- No significant changes were observed in blood plasma or breast muscle lipid peroxide status.
Conclusions:
- Acute monensin poisoning substantially enhances lipid peroxidation in the broiler chicken liver.
- Monensin overdosage does not significantly affect lipid peroxide status in blood plasma or breast muscle.
- The precise role of these oxidative changes in monensin poisoning pathogenesis requires further investigation.