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Related Experiment Videos

Electroretinographical changes due to antimicrobials.

K Kawasaki1, K Mochizuki, M Torisaki

  • 1Department of Ophthalmology, Kanazawa University School of Medicine, Japan.

Lens and Eye Toxicity Research
|January 1, 1990
PubMed
Summary
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This study assessed the retinal toxicity of various antimicrobials after intravitreal injection in rabbits. Recommended clinical dosages were determined for safe and effective use in ophthalmic treatments.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Toxicology

Background:

  • Intravitreal injections of antimicrobials are crucial for treating endophthalmitis.
  • Assessing the retinal safety profile of these agents is essential for clinical practice.

Purpose of the Study:

  • To evaluate the retinal toxicity of a panel of antimicrobials administered via single-shot intravitreal injection in a rabbit model.
  • To establish recommended clinical dosages for these antimicrobials to minimize retinal toxicity.

Main Methods:

  • Electroretinography (ERG) was used to assess retinal function before and after intravitreal injections.
  • A range of antimicrobial agents including beta-lactams, aminoglycosides, fluoroquinolones, and an antifungal were tested.
  • Dose-ranging studies were conducted to determine the safety threshold for each agent.

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Main Results:

  • Specific dosages were identified for each antimicrobial agent that did not induce significant retinal toxicity as measured by ERG.
  • Gentamicin, netilmicin, amikacin, and tobramycin showed potential for retinal toxicity at higher concentrations.
  • Vancomycin and flomoxef demonstrated a favorable safety profile at the recommended doses.

Conclusions:

  • The study provides crucial data on the retinal safety of commonly used antimicrobials for intravitreal administration.
  • Recommended dosages can guide ophthalmologists in selecting appropriate antimicrobial agents and doses to prevent ocular toxicity.
  • Further clinical correlation is warranted to confirm these findings in human patients.