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Physico-chemical characterization of a new salt of ibuprofen
M S Suleiman1, N M Najib, M A Hassan
1Faculty of Pharmacy, Jordan University of Science and Technology, Irbid.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1990
Abstract:
A new salt of ibuprofen was prepared by reaction with t-butylamine; its formation was confirmed by IR and 1H-NMR spectroscopy. The salt was characterized by thermoanalytical, X-ray powder diffraction and solubility studies. The salt was found to be 1.5 times more soluble in water than was ibuprofen, with an enthalpy of solution of -8.84 kcal mol-1.