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Indirect continuous automatic determination of pharmaceuticals by atomic absorption spectroscopy.

M Valcárcel¹, M Gallego, R Montero

¹Department of Analytical Chemistry, University of Córdoba, Spain.

Journal of Pharmaceutical and Biomedical Analysis

|January 1, 1990

Summary

This study details continuous separation techniques for analyzing pharmaceutical and biological samples. These methods offer sensitive, selective, and rapid determination of active components using flow injection analysis (FIA) coupled with atomic absorption spectrometry.

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Area of Science:

Analytical Chemistry
Separation Science
Spectroscopy

Background:

Pharmaceutical and biological fluid analysis requires accurate determination of active components.
Traditional methods can be time-consuming and less efficient.

Purpose of the Study:

To describe the implementation of continuous separation techniques in flow injection analysis (FIA) manifolds.
To determine active components in pharmaceuticals and biological fluids using on-line atomic absorption spectrometry.

Main Methods:

Utilized continuous separation techniques: precipitation, liquid-liquid extraction, and solid-liquid extraction.
Coupled FIA manifolds on-line with an atomic absorption spectrometer.
Analyzed sulphonamides, local anaesthetics, amphetamines, benzodiazepines, chloramphenicol, and methadone.

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Main Results:

Systematic description of analytical methodologies.
Evaluation of sensitivity, selectivity, precision, and rapidity.
Critical comparison of the described analytical features.

Conclusions:

Continuous separation techniques integrated with FIA and atomic absorption spectrometry are effective for analyzing active components.
The methodologies offer advantages in terms of sensitivity, selectivity, precision, and speed.
These on-line methods provide a robust approach for pharmaceutical and biological sample analysis.