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Inclusion complexation of doxorubicin and daunorubicin with cyclodextrins
O Bekers1, J H Beijnen, M Otagiri
1Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, The Netherlands.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1990
Abstract:
The interaction of alpha-, beta- and gamma-cyclodextrins with the anthracycline antibiotics doxorubicin and daunorubicin was investigated by LC, circular dichroism (CD) and absorption spectroscopy. All studies were performed in aqueous media at different temperatures and pH values. The anthracyclines complex only with gamma-cyclodextrin. Lineweaver-Burk and Scott's plots were used to calculate the stability constants of the anthracycline-gamma-cyclodextrin inclusion complexes.