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Development of a microcomputer program for statistical evaluation of potential pharmacokinetic drug interactions
R Soto-Otero1, E Mendez-Alvarez, J L Otero-Cepeda
1Department of Biochemistry and Molecular Biology, School of Medicine, University of Santiago, Spain.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1990
Summary
This study presents a BASIC program for statistically evaluating drug interactions. It aids in comparing pharmacokinetic parameters from different populations using graphic computing techniques.
Area of Science:
- Pharmacokinetics
- Computational Biology
- Drug Interaction Studies
Background:
- Statistical evaluation of drug interactions is crucial for understanding pharmacokinetics.
- Existing methods may lack accessibility or flexibility for complex pharmacokinetic models.
Purpose of the Study:
- To describe a user-friendly BASIC program for the statistical evaluation of potential drug interactions.
- To enable the determination and comparison of pharmacokinetic parameters using graphic computing.
Main Methods:
- Development of a simple, subroutine-organized BASIC program.
- Utilizes data from two populations (time and drug concentration).
- Incorporates graphic computing techniques for analysis.
Main Results:
- The program facilitates statistical comparison of pharmacokinetic parameters.
- It supports one- and two-compartment open models for intravenous and extravasal administration.
- Parameters like disposition constants and area under the concentration-time curves can be determined.
Conclusions:
- The described program offers a straightforward tool for pharmacokinetic drug interaction analysis.
- Its subroutine structure allows for easy modification and extension to diverse pharmacokinetic models.