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Related Experiment Videos

Delayed cutaneous hypersensitivity after multiple injury and severe burn.

M Imhoff1, R H Gahr, P Hoffmann

  • 1Department of Surgery, Städtische Kliniken, Dortmund, West Germany.

Annali Italiani Di Chirurgia
|September 1, 1990
PubMed
Summary

Delayed hypersensitivity testing using Multitest Mérieux effectively predicts infectious complications and prognosis in trauma patients. The extent of injury correlates with anergy, aiding in patient assessment.

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Area of Science:

  • Immunology
  • Trauma Surgery
  • Critical Care Medicine

Background:

  • Prognosis in multiple injury and severe burn patients heavily relies on infectious complications and immunological response.
  • The extent of trauma significantly influences immune reactions.
  • Assessing delayed hypersensitivity is crucial for predicting patient outcomes.

Purpose of the Study:

  • To evaluate the predictive capability of Multitest Mérieux for prognosis in multiply injured and severely burnt patients.
  • To determine if Multitest Mérieux can guide new therapeutic recommendations.
  • To investigate the correlation between trauma severity and immune response.

Main Methods:

  • A study involving 52 patients (16 severe burns, 20 multiple injuries with craniocerebral trauma, 16 without) in 1985.

Related Experiment Videos

  • Standard laboratory and cardiopulmonary parameters were monitored every 48 hours post-injury.
  • Delayed hypersensitivity testing (DHT) was performed using Multitest Mérieux, with trauma severity assessed by Injury Severity Score (ISS).

    • Main Results:

    • Quantitative laboratory and cardiopulmonary parameters did not significantly correlate with the clinical course.
    • A significant correlation was found between Multitest Mérieux reactions (at days 6 and 8, and overall) and the incidence of infectious complications.
    • Higher ISS scores positively correlated with anergic reactions in the Multitest Mérieux, indicating a suppressed immune response.

    Conclusions:

    • Multitest Mérieux is a reliable and easily applicable tool for assessing prognosis in patients with multiple injuries and severe burns.
    • The test aids in predicting infectious complications and overall patient outcomes.
    • Current intensive care concepts remain the standard; no new therapeutic recommendations beyond these were identified.