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Thyroidectomy reduces stress-induced prolactin secretion in rats. Participation of brain serotonergic systems
M J Ramalho1, L C Reis, K Nonaka
1Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo.
Abstract:
Plasma prolactin levels were measured in thyroidectomized and sham-operated rats under immobilization stress. Thyroidectomy significantly reduced prolactin secretion during stress. The pretreatment of thyroidectomized rats with 6-chloro-2-[1-piperazinyl]- pyrazine (MK 212), a serotonin agonist that easily penetrates the blood-brain barrier, reversed the reduction in stress-induced prolactin release in the thyroidectomized group.