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Bioeffects of the plant Mahonia sempervirens
1Cantacuzino Institute, Bucharest, Romania.
Archives Roumaines De Pathologie Experimentales Et De Microbiologie
|April 1, 1990
Summary
Water extracts from Mahonia sempervirens fruits exhibit hemagglutinin, hemolysin, and anticomplementary activities. The study separated the red pigment, finding it distinct from the complement inhibitor.
Area of Science:
- Phytochemistry
- Immunology
- Pharmacology
Background:
- Mahonia sempervirens fruit extracts display multiple biological activities.
- Understanding these properties is crucial for potential therapeutic applications.
Purpose of the Study:
- To characterize the biological properties of Mahonia sempervirens fruit water extracts.
- To investigate the relationship between the fruit's red pigment and its anticomplementary activity.
Main Methods:
- Partial characterization using spectrophotometry, electrophoresis, and chromatography.
- Fractionation via ionic exchange static adsorption chromatography.
Main Results:
- The extract exhibited hemagglutinin, hemolysin, complement antagonism, and antistreptococcal activity.
- Quantitative separation of the red pigment was achieved.
- The anticomplementary activity was fully recovered and found to be separate from the pigment and other activities.
Conclusions:
- The complement inhibitor in Mahonia sempervirens fruit extract is distinct from its hemagglutinin, hemolysin, and red pigment.
- Further research can explore the therapeutic potential of this isolated complement inhibitor.