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Frequency of the -alpha 3.7 thalassemia deletion in the non-white Cuban population
G Martinez1, R Ferreira, A Hernandez
1Instituto de Hematologia e Inmunologia, La Habana, Cuba.
Gene Geography : a Computerized Bulletin on Human Gene Frequencies
|August 1, 1990
Abstract:
DNA analysis of the alpha-globin gene cluster showed that the frequency of the -alpha 3.7 deletion in the non-white cuban population is about 0.12, in agreement with a 47% admixture of the original African slaves introduced in the island. In the S-S homozygotes the frequency is slightly higher (.18), probably due to a selective advantage produced by the presence of alpha-thalassemia in sickle cell patients.