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[Cardioscintigraphic evaluation of obese subjects with or without arterial hypertension]
S Ferraro1, M Santomauro, G Maddalena
1Istituto di Medicina Interna, Cardiologia e Cardiochirurgia, Università di Napoli.
Insights
Obesity combined with hypertension significantly impacts cardiac function, potentially worsening prognosis. Obese individuals with hypertension show better cardiac function than those without, but overall cardiac workload is highest in this group.
Area of Science:
- Cardiology
- Nuclear Medicine
- Obesity Research
Background:
- Obesity is a growing public health concern associated with cardiovascular disease.
- Hypertension is a major risk factor for heart disease.
- Understanding cardiac function in obese individuals with and without hypertension is crucial.
Purpose of the Study:
- To investigate cardiac function and hemodynamics in normotensive obese subjects.
- To assess cardiac function and hemodynamics in hypertensive obese subjects.
- To compare cardiac function between obese subjects with and without hypertension and control subjects.
Main Methods:
- Radionuclide ventriculography using 99mTc was performed on three groups: normotensive obese (A), hypertensive obese (B), and controls (C).
- Cardiac function and hemodynamic parameters were evaluated under conditions of increased preload (A) and increased preload with afterload (B).
Main Results:
- Normotensive obese subjects (A) exhibited a significant reduction in ejection fraction and systolic blood pressure/end systolic volume.
- Hypertensive obese subjects (B) demonstrated preserved cardiac function, potentially due to concentric hypertrophy.
- Left ventricular work (minute and beat) was highest in hypertensive obese subjects (B).
Conclusions:
- Obesity alone, with increased preload, impairs cardiac function.
- Obesity with coexisting hypertension may lead to better preserved cardiac function, possibly due to hypertrophy.
- The combination of obesity and hypertension indicates a worse prognosis, increasing the risk of cardiac ischemia and sudden death.
Abstract:
A group of normotensive obese subjects (group A), a group of hypertensive obese subjects (group B) and a group of control subjects (group C) were submitted to radionuclide ventriculography using 99mTc to investigate cardiac function and haemodynamic situation in the presence of an increased preload (group A), preload and afterload (group B). Results show a significant reduction in ejection fraction and systolic blood pressure/end systolic volume in group A. Group B shows better cardiac function probably for the presence of cardiac concentric hypertrophy. Left ventricle work either in a minute and for each beat is greatest in patients of group B. Thus the simultaneous presence of obesity and hypertension can cause a worse prognosis in such patients for cardiac ischaemia and/or sudden death.