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[The radiation sensitizing activity of metronidazole and iso-metronidazole
S J Proskurjakov1, O A Smoryzanova, N I Rjabcenko
1Labor für Molekularbiologie, AdmW, UdSSR, Obninsk.
Radiobiologia, Radiotherapia
|January 1, 1990
Abstract:
The effect of irradiation, metronidazole and iso-metronidazole on survival and number of tumor cells was analysed in vitro in mice that were inoculated with La-hemocytoblastosis--or Ehrlich-ascites-tumor cells after processing. It was shown that metronidazole and iso-metronidazole nearly have the same radiosensitizing activity on these conditions. The effect was dependent on concentration of compounds and cell type. With intraperitoneal application the iso-metronidazole was eliminated from Lewis-lung-carcinoma more slowly than from blood.