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[Contraceptives and ischemic cardiopathy]
I García-Bolao1, E Alegría, I Iglesias
1Departamento de Cardiología y Cirugía Cardiovascular, Facultad de Medicina, Universidad de Navarra, Pamplona.
Abstract:
The incidence of myocardial infarction is higher in women that use oral contraceptives. The most important pathophysiologic mechanisms are: a) modification of coronary risk factors: the pill produces an elevation of both serum cholesterol and trygliceride levels, increase of blood pressure and decompensation of diabetes mellitus; b) blood coagulation disorders: oral contraceptives increase platelet aggregation and fibrinogen blood levels, therefore they have a considerable thrombogenic capacity. At this moment there are several update publications concerning this matter; however most of the mechanisms involved in the increase of coronary heart disease in this specific group still remain unclear.