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Transmembrane communication and disease.

C A Pasternak1

  • 1Department of Cellular and Molecular Sciences, St George's Hospital Medical School, University of London, UK.

Indian Journal of Biochemistry & Biophysics
|December 1, 1990
PubMed
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Cell surface interactions are crucial for cell communication. Divalent cations protect against membrane damage, while stress increases glucose uptake via transporter translocation.

Area of Science:

  • Cell Biology
  • Biochemistry

Background:

  • Cell surface interactions mediate critical cellular functions, including communication across the plasma membrane.
  • Diseases can disrupt cell behavior by altering these surface interactions.

Purpose of the Study:

  • To present two examples of how cell surface alterations affect cell behavior.
  • To highlight the role of divalent cations in preventing membrane damage.
  • To explain the mechanism of increased glucose uptake under stress conditions.

Main Methods:

  • Investigated the induction of pores in cell membranes by various agents (viruses, toxins, immune molecules).
  • Examined the protective effect of divalent cations (Ca2+, Zn2+) against membrane damage.
  • Studied the impact of different stress stimuli (hyperthermia, toxic chemicals, viral infections) on cellular glucose uptake.

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Main Results:

  • Diverse agents can induce pores, compromising cell membrane integrity.
  • Divalent cations effectively prevent membrane damage caused by pore formation.
  • Various stresses lead to increased glucose uptake through the translocation of glucose transporter proteins to the plasma membrane.

Conclusions:

  • Cell surface integrity and communication are vital and susceptible to disruption.
  • Divalent cations offer a protective mechanism against membrane damage.
  • Stress-induced glucose uptake involves a regulated transporter translocation pathway, similar to insulin signaling.