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Published on: April 4, 2011
Anticardiolipin antibodies in HIV-negative and HIV-positive haemophiliacs
N Naimi1, C Plancherel, C Bosser
1Department of Medicine, University Hospital, Geneva, Switzerland.
Insights
Anticardiolipin antibodies (ACA) were found exclusively in HIV-infected hemophiliacs. However, ACA presence did not correlate with disease progression in this patient group.
Area of Science:
- Immunology
- Hematology
- Virology
Background:
- Hemophilia is a bleeding disorder often requiring frequent blood transfusions.
- Human Immunodeficiency Virus (HIV) infection can affect various bodily systems.
- Anticardiolipin antibodies (ACA) are autoantibodies associated with thrombotic events.
Purpose of the Study:
- To investigate the prevalence of anticardiolipin antibodies (ACA) in heavily transfused hemophiliacs.
- To determine the association between ACA and HIV infection in hemophiliacs.
- To explore the relationship between ACA and disease progression in HIV-infected hemophiliacs.
Main Methods:
- Blood samples were collected from 72 hemophiliacs (43 HIV-positive, 29 HIV-negative).
- Anticardiolipin antibodies (ACA) were measured using serological tests.
- Patients were categorized based on HIV infection status and clinical stage (CDC II, III, IV).
Main Results:
- ACA were detected in 10 patients, all of whom were HIV-positive.
- ACA prevalence was 0% in HIV-negative hemophiliacs and 23.3% (10/43) in HIV-positive hemophiliacs.
- No statistically significant difference in other laboratory markers was observed between ACA-positive and ACA-negative HIV-infected patients.
- ACA presence was not associated with disease progression (AIDS) in HIV-infected hemophiliacs.
Conclusions:
- Anticardiolipin antibodies are specifically found in HIV-infected hemophiliacs.
- ACA detection in this cohort is linked to HIV infection, not hemophilia itself.
- The presence of ACA does not appear to predict or influence the progression of HIV/AIDS in hemophiliac patients.
Abstract:
Anticardiolipin antibodies (ACA) were determined in 72 heavily transfused haemophiliacs, 43 HIV-positive and 29 HIV-negative. The presence of ACA was detected in 10 patients, all of them infected by HIV: 8 in CDC II, 1 in CDC III and 1 in CDC IV. The comparison with alterations of other laboratory markers in HIV-infected patients did not show any statistically significant difference between ACA-negative and -positive patients. In summary, ACA were found only in HIV-infected haemophiliacs. In this subgroup of patients the presence of ACA was not associated with progression to AIDS.
