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Published on: September 15, 2017
Pheochromocytoma presenting with Takotsubo syndrome
Pamela A Marcovitz1, Peter Czako, Solomon Rosenblatt
1William Beaumont Hospital, Royal Oak, Michigan 48073, USA. pmarcovitz@beaumonthospitals.com
Insights
Takotsubo syndrome, mimicking heart attacks, can be caused by pheochromocytoma. This rare case highlights the importance of considering adrenal tumors in stress-induced cardiomyopathy diagnosis.
Area of Science:
- Cardiology
- Endocrinology
- Oncology
Background:
- Takotsubo syndrome (apical ballooning syndrome) clinically mimics myocardial infarction.
- It presents with chest pain and ECG changes but normal coronary arteries.
- Stress-induced catecholamine surge is a common suspected mechanism.
Observation:
- A patient presented with atypical Takotsubo syndrome symptoms.
- The patient had a pheochromocytoma, a rare adrenal tumor.
Findings:
- Pheochromocytoma was identified as the underlying cause of Takotsubo syndrome in this case.
- A rapid blood pressure increase post-echocardiographic stress testing led to the diagnosis.
Implications:
- This case expands the differential diagnosis for Takotsubo syndrome.
- It underscores the need to investigate potential endocrine causes, like pheochromocytoma, in specific clinical scenarios.
- Early diagnosis of pheochromocytoma is crucial for managing associated cardiovascular risks.
Abstract:
The clinical presentation of Takotsubo syndrome, or apical ballooning syndrome, resembles an extensive anterolateral myocardial infarction with chest pain symptoms and electrocardiographic ST-elevation or T-wave inversion noted in most patients. However, coronary arteries are invariably found to be normal or to display minimal atherosclerotic disease despite modest elevation of cardiac enzymes. Since most cases of Takotsubo syndrome occur after intense physical and/or emotional stress, catecholamine surge appears to be a common underlying mechanism. We present a case of Takotsubo syndrome, which presented with unusual symptoms and was found to be caused by pheochromocytoma. A sudden rise in blood pressure moments after completion of echocardiographic stress testing aided in uncovering the diagnosis.
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