Related Experiment Video

Updated: Jun 7, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Transient hyperphosphatasemia in children revisited

Neta Dori1, Lily Levi, Tamar Stam

  • 1Department of Pediatrics Pediatric Surgery, Bnai Zion Medical Center, Maccabi Health Services, Haifa, Israel.

Pediatrics International : Official Journal of the Japan Pediatric Society
|October 30, 2010
PubMed

Insights

Transient hyperphosphatasemia (TH) in children often presents with elevated bone alkaline phosphatase (ALP) and is frequently diagnosed in the latter half of the year. The exact cause remains unclear, suggesting a complex mechanism involving various stimuli.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Biochemistry
  • Medical Diagnostics

Background:

  • Transient hyperphosphatasemia (TH) is a recognized condition, yet its origins and underlying mechanisms are not fully understood.
  • Existing knowledge on TH lacks detailed clinical characterization, particularly in pediatric populations.

Purpose of the Study:

  • To investigate the clinical features of children diagnosed with TH.
  • To compare current findings with previous studies to enhance understanding of TH.
  • To identify potential subgroups of children at higher risk for developing TH.

Main Methods:

  • Retrospective analysis of 60 children diagnosed with TH between 2003-2008.
  • Inclusion of 122 age, gender, and symptom-matched controls.
  • Categorization of patients into subgroups based on presenting symptoms (infectious disease, failure to thrive, diarrhea, other).
  • Utilized Hydragel ISO-PAL kits for ALP isoenzyme analysis.

Main Results:

  • Elevated alkaline phosphatase (ALP) levels (mean 2311 U/L) were observed in TH patients, with no significant differences across symptom subgroups.
  • The average duration of TH was 12 weeks.
  • Bone isoenzyme of ALP was elevated in most analyzed cases.
  • A majority of diagnoses (71%) occurred in the second half of the calendar year.

Conclusions:

  • No definitive etiological explanation for TH was established in this study.
  • TH is presumed to result from a complex interplay of factors leading to enzyme upregulation.
  • Further research is needed to elucidate the precise pathophysiology of TH.
Abstract

More Related Videos

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...