Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparison of lung scintigraphy with multi-slice spiral computed tomography in the diagnosis of pulmonary embolism.

Clinical nuclear medicine·2009

Same author

[Analysis on the characters of injuries in body surface and deduction of injury-causing instruments in 146 cases].

Fa yi xue za zhi·2009

Same author

Impact of ketone and amino on the inner shell of guanine.

Journal of synchrotron radiation·2009

Same author

Actin turnover is required for myosin-dependent mitochondrial movements in Arabidopsis root hairs.

PloS one·2009

Same author

Direct observation of a widely tunable bandgap in bilayer graphene.

Nature·2009

Same author

Investigation of second-order nonlinearity in poled-polymer during photobleaching.

Optics express·2009

Search research articles

Related Experiment Video

Updated: Jun 7, 2026

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers

Published on: January 28, 2020

The relationship between early embryo development and tumourigenesis.

Yanlei Ma¹, Peng Zhang, Feng Wang

¹Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.

Journal of Cellular and Molecular Medicine

|October 30, 2010

Summary

Early embryo development and tumor formation share striking similarities in cellular behaviors and gene regulation. Understanding these links offers new avenues for cancer prognosis and therapy.

More Related Videos

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Published on: July 25, 2017

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Related Experiment Videos

Last Updated: Jun 7, 2026

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers

Published on: January 28, 2020

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Published on: July 25, 2017

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Area of Science:

Developmental Biology
Cancer Biology
Epigenetics

Background:

Recent advances highlight parallels between embryonic development and tumorigenesis.
The interplay between tumors and embryos is increasingly recognized.

Purpose of the Study:

To review the embryonic origins of tumors.
To detail similarities between early development and tumorigenesis.
To explore developmental biology approaches for cancer treatment.

Main Methods:

Comparative analysis of cell invasive behaviors.
Review of epigenetic regulation in development and cancer.
Examination of gene expression and protein profiling similarities.

Main Results:

Embryonic and tumor cells exhibit comparable invasive properties.
Shared epigenetic mechanisms and gene expression patterns are observed.
Protein profiles show similarities between developmental and cancerous states.

Conclusions:

The relationship between early development and tumorigenesis provides novel insights.
Developmental biology offers a framework for innovative cancer therapies.
Next-generation prognostic and therapeutic strategies can emerge from this understanding.