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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
[Carbapenem resistance in gram-negative bacteria]
Marc J M Bonten1, Jan Kluytmans, Bart Jan Kulberg
1Universitair Medisch Centrum Utrecht, Utrecht, afd. Medische Microbiologie, the Netherlands. mbonten@umcutrecht.nl
Nederlands Tijdschrift Voor Geneeskunde
|October 30, 2010
Summary
Antibiotic resistance is a major threat in hospitals. Klebsiella pneumoniae carbapenemases (KPCs) are a growing concern, necessitating strict antibiotic use and infection control to prevent spread in Dutch hospitals.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Public Health
Background:
- Antibiotic resistance is a critical global health challenge.
- Carbapenemase-producing organisms, like Klebsiella pneumoniae carbapenemases (KPCs), are emerging threats.
- Hospitalized patients are particularly vulnerable to resistant infections.
Purpose of the Study:
- To highlight the growing threat of carbapenemase-producing Klebsiella pneumoniae in hospital settings.
- To emphasize the importance of infection control and antibiotic stewardship in managing KPC spread.
- To provide recommendations for limiting KPC transmission in Dutch hospitals.
Main Methods:
- Literature review on carbapenemase-producing organisms.
- Analysis of current infection control practices.
- Assessment of antibiotic usage patterns in healthcare settings.
Main Results:
- Klebsiella pneumoniae carbapenemases (KPCs) represent a significant advancement in antibiotic resistance.
- Effective infection control measures are vital to curb the spread of KPCs.
- Judicious antibiotic use is essential to mitigate resistance development.
Conclusions:
- Combating KPC spread requires a dual approach: stringent infection control and restricted antibiotic use.
- Proactive strategies are necessary to preserve the efficacy of antibiotics in clinical practice.
- The Netherlands must implement these measures to control KPC in hospitals.
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